I use twitter for a year now. It's great, but since the last half year it seems to fall because of it's popularity. I don't mean the downtimes of the servers, but the enormous flood of information caused by all the people I follow. I can't keep up with it, but I don't want to miss important information too, especially the twitters which seem to be meant for me, like replies.
All replies can be recgonized, because people would add @tjosinga to those twitters (tjosinga is my username of twitter). That fact can be used. All you need is a RSS feed filter and the URL of Twitter's RSS.
I assume I'm not the first person who figured this out. And there are probably thousands solutions.
The URL can be found on your Twitter's homepage. Down below you can find a button RSS. Rightclick it and 'copy the location'. Later you can add that in the RSS filter. Be sure to add your Twitter credentials to the URL, so you get something like this:
http://username:password@twitter.com/statuses/friends_timeline/xxxxxxx.rss
As filter I used Yahoo Pipes in which I created the following pipe:
All it does is fetching the twitters using RSS feed, filters out all twitters which doesn't contain @tjosinga and outputs all twitter which do contain that. After running the pipe I can grab that output as a new RSS feed and read that with my favorite RSS feed reader (currently Mac's Mail application, because that's open all the time).